Yeah, sure, we basically knew The Lizard was going to be the villain in the upcoming Spider-Man movie, but no one has really come out and said that Spider-Man will be battling The Lizard. We knew Rhys Ifans was playing Dr. Curt Connors, whose alter-ego is The Lizard, but considering the fact that Connors also appears in the other Spider-Man movies sans Lizard, we need to be extra sure this time that the character is at some point going to turn into a nasty lizard and battle Spidey. Thankfully, C. Thomas Howell – who has a bit part in the film – has confirmed this to be true. 
He says (via Movieweb), "There is not a whole lot to talk about. Sony wants us to be hush-hush right now. I play a relatively small role. I play a construction worker whose son is caught in the middle of a battle between the Lizard and Spider-Man on the Manhattan bridge. Spider-Man helps me get my son back from this perilous situation. There is some payback there at the end of the movie. Spider-man is kind of hurting. I help him when all of the other people won't. Part of the story is, the nation thinks he might be a bad guy. They don't know what to think. Because of my experience on the bridge with my kid, I know he is a good guy. I pitch in and help out at the end. That is the best way."
So what do you think? Another Spider-Man battle on a Manhattan bridge? Could it work?
